Open AccessNF‐ κ B activation in melanoma
Author(s) -
Ueda Yukiko,
Richmond Ann
Publication year - 2006
Publication title -
pigment cell research
Language(s) - English
Resource type - Journals
eISSN - 1600-0749
pISSN - 0893-5785
DOI - 10.1111/j.1600-0749.2006.00304.x
Subject(s) - melanoma , downregulation and upregulation , nf κb , cancer research , transcription factor , autocrine signalling , nfkb1 , cancer , apoptosis , gene , medicine , biology , receptor , genetics
Summary Metastatic melanoma is an aggressive skin cancer that is notoriously resistant to current cancer therapies. In human melanoma, nuclear factor‐kappa B (NF‐ κ B) is upregulated, leading to the deregulation of gene transcription. In this review, we discuss (i) the relationship between gene alteration in melanoma and upregulation of NF‐ κ B, (ii) mechanisms by which activated NF‐ κ B switch from pro‐apoptotic to anti‐apoptotic functions in melanoma and (iii) autocrine mechanisms that promote constitutive activation of NF‐ κ B in metastatic melanoma.