NF‐ κ B activation in melanoma | Zendy

Ueda Yukiko | Zendy; Richmond Ann | Zendy

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NF‐ κ B activation in melanoma

Author(s) -

Ueda Yukiko,

Richmond Ann

Publication year - 2006

Publication title -

pigment cell research

Language(s) - English

Resource type - Journals

eISSN - 1600-0749

pISSN - 0893-5785

DOI - 10.1111/j.1600-0749.2006.00304.x

Subject(s) - melanoma , downregulation and upregulation , nf κb , cancer research , transcription factor , nfkb1 , autocrine signalling , apoptosis , cancer , gene , medicine , biology , receptor , genetics

Summary Metastatic melanoma is an aggressive skin cancer that is notoriously resistant to current cancer therapies. In human melanoma, nuclear factor‐kappa B (NF‐ κ B) is upregulated, leading to the deregulation of gene transcription. In this review, we discuss (i) the relationship between gene alteration in melanoma and upregulation of NF‐ κ B, (ii) mechanisms by which activated NF‐ κ B switch from pro‐apoptotic to anti‐apoptotic functions in melanoma and (iii) autocrine mechanisms that promote constitutive activation of NF‐ κ B in metastatic melanoma.

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