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Localization of c‐ MYB in differentiated cells during postnatal molar and alveolar bone development
Author(s) -
Lungova Vlasta,
Buchtova Marcela,
Janeckova Eva,
Tucker Abigail S.,
Knopfova Lucia,
Smarda Jan,
Matalova Eva
Publication year - 2012
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.2012.01004.x
Subject(s) - cementoblast , myb , odontoblast , immunohistochemistry , ameloblast , bone sialoprotein , microbiology and biotechnology , chemistry , cellular differentiation , mineralized tissues , biology , transcription factor , alkaline phosphatase , pathology , immunology , biochemistry , cementum , dentin , enamel paint , osteocalcin , medicine , dentistry , enzyme , gene
The MYB family of transcription activators has been associated with a high proliferation rate and an undifferentiated state of cells in a number of tissues. Recently emerging data suggest that these molecules may also play a role in differentiation. In this study, the pattern of expression of c‐ MYB was followed during postnatal stages of mouse molar odontogenesis using immunohistochemistry on serial sections. Along with an abundance of the c‐ MYB protein in proliferating zones, we confirmed the presence of this protein in differentiated ameloblasts, odontoblasts, and osteoblasts. In addition, c‐ MYB was also found in cementoblasts and alveolar fibroblasts. These findings suggest integration of c‐ MYB into regulatory networks during hard‐tissue differentiation and mineralization.