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Requirement of alveolar bone formation for eruption of rat molars
Author(s) -
Wise Gary E.,
He Hongzhi,
Gutierrez Dina L.,
Ring Sherry,
Yao Shaomian
Publication year - 2011
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.2011.00854.x
Subject(s) - molar , dental alveolus , tooth eruption , dentistry , periodontal fiber , dental follicle , bone resorption , bone remodeling , medicine , chemistry , orthodontics , pathology , mesenchymal stem cell
Wise GE, He H, Gutierrez DL, Ring S, Yao S . Requirement of alveolar bone formation for eruption of rat molars .
Eur J Oral Sci 2011; 119: 333–338 . © 2011 Eur J Oral Sci Tooth eruption is a localized event that requires a dental follicle (DF) to regulate the resorption of alveolar bone to form an eruption pathway. During the intra‐osseous phase of eruption, the tooth moves through this pathway. The mechanism or motive force that propels the tooth through this pathway is controversial but many studies have shown that alveolar bone growth at the base of the crypt occurs during eruption. To determine if this bone growth (osteogenesis) was causal, experiments were designed in which the expression of an osteogenic gene in the DF, bone morphogenetic protein‐6 ( Bmp6 ), was inhibited by injection of the first mandibular molar of the rat with a small interfering RNA (siRNA) targeted against Bmp6 . The injection was followed by electroporation to promote uptake of the siRNA. In 45 first molars injected, eruption was either delayed or completely inhibited (seven molars). In the impacted molars, an eruption pathway formed but bone growth at the base of the crypt was greatly reduced compared with the erupted first‐molar controls. These studies show that alveolar bone growth at the base of the crypt is required for tooth eruption and that Bmp6 may be essential for promoting this growth.