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Effect of diabetes on orthodontic tooth movement in a mouse model
Author(s) -
Braga Sarah M. G.,
de Albuquerque Taddei Silvana R.,
Andrade Ildeu,
QueirozJunior Celso M.,
Garlet Gustavo P.,
Repeke Carlos E.,
Teixeira Mauro M.,
da Silva Tarcília A.
Publication year - 2011
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.2010.00793.x
Subject(s) - osteoclast , dental alveolus , rankl , periodontium , bone remodeling , endocrinology , medicine , diabetes mellitus , osteoblast , dentistry , chemistry , receptor , biochemistry , activator (genetics) , in vitro
Braga SMG, de Albuquerque Taddei SR, Andrade I Jr, Queiroz‐Junior CM, Garlet GP, Repeke CE, Teixeira MM, da Silva TA. Effect of diabetes on orthodontic tooth movement in a mouse model. Eur J Oral Sci 2011; 119: 7–14. © 2011 Eur J Oral Sci Orthodontic tooth movement is achieved by the remodeling of alveolar bone in response to mechanical loading. Type 1 diabetes results in bone remodeling, suggesting that this disease might affect orthodontic tooth movement. The present study investigated the effects of the diabetic state on orthodontic tooth movement. An orthodontic appliance was placed in normoglycemic (NG), streptozotocin‐induced diabetes (DB), and insulin‐treated DB (IT) C57BL6/J mice. Histomorphometric analysis and quantitative PCR of periodontium were performed. The DB mice exhibited greater orthodontic tooth movement and had a higher number of tartrate‐resistant acid phosphate (TRAP) ‐positive osteoclasts than NG mice. This was associated with increased expression of factors involved in osteoclast activity and recruitment ( Rankl , Csf1 , Ccl2 , Ccl5 , and Tnfa ) in DB mice. The expression of osteoblastic markers ( Runx2 , Ocn , Col1 , and Alp ) was decreased in DB mice. Reversal of the diabetic state by insulin treatment resulted in morphological findings similar to those of NG mice. These results suggest that the diabetic state up‐regulates osteoclast migration and activity and down‐regulates osteoblast differentiation, resulting in greater orthodontic tooth movement.