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Aquaporin 11 in the developing mouse submandibular gland
Author(s) -
Larsen Helga S.,
Ruus AnnKristin,
Schreurs Olav,
Galtung Hilde Kanli
Publication year - 2010
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.2009.00708.x
Subject(s) - aquaporin , submandibular gland , biology , aquaporin 2 , salivary gland , embryogenesis , duct (anatomy) , in situ hybridization , endocrinology , medicine , gene , embryo , microbiology and biotechnology , anatomy , messenger rna , genetics , water channel , mechanical engineering , engineering , inlet
Larsen HS, Ruus A‐K, Schreurs O, Kanli Galtung H. Aquaporin 11 in the developing mouse submandibular gland. Eur J Oral Sci 2010; 118: 9–13. © 2010 The Authors. Journal compilation © 2010 Eur J Oral Sci Several aquaporins (AQPs) have been detected in mature and embryonic mammalian salivary glands (AQP1 and AQP3–AQP8). However, AQP11 has, to our knowledge, never before been described in salivary glands, but is known to be important in, for example, kidney development in mice. We therefore thought it relevant to investigate if AQP11 was present during salivary organogenesis. The submandibular salivary gland (SMG) from CD1 mice was studied during prenatal development and early postnatal development, and also in young adult male and female mice. The expression trend of the AQP11 transcript was detected using the reverse transcription–polymerase chain reaction (RT‐PCR), and the temporal–spatial pattern was observed using in situ hybridization. The AQP11 transcript was first detected at embryonic day 13.5 and showed a more or less constitutive expression trend during the prenatal and early postnatal SMG development. Spatial studies demonstrated that the AQP11 transcript was present in the developing and mature duct structures at all stages studied. In the end pieces, the AQP11 transcript was reduced during glandular development. Our results point to an important role for AQP11 during salivary gland development.