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Dynamic changes in bone metabolism in the rat temporomandibular joint after molar extraction using bone scintigraphy
Author(s) -
Yokoyama Masayoshi,
Atsumi Tomohiro,
Tsuchiya Masahiro,
Koyama Shigeto,
Sasaki Keiichi
Publication year - 2009
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.2009.00635.x
Subject(s) - condyle , molar , temporomandibular joint , osteoclast , bone remodeling , chemistry , osteoprotegerin , bone scintigraphy , extraction (chemistry) , dentistry , orthodontics , endocrinology , medicine , nuclear medicine , biochemistry , chromatography , activator (genetics) , in vitro , gene
Functional adaptation with reformation of bone tissue structure occurs after changes in mechanical stress distribution. To examine how occlusal changes affect the dynamics of bone metabolism in the mandibular condyle, bone scintigraphy of rat condyles was taken using 99m technetium‐methylene‐diphosphonate ( 99m Tc‐MDP) after extraction of maxillary molars resulting in unilateral loss of occlusal support. Accumulation of 99m Tc‐MDP was significantly higher in the condyles on the extracted side than on the intact side 3 d after molar extraction. In addition, bone mineral density (BMD) and osteoprotegerin expression in extracted‐side condyles were significantly increased while osteoclast numbers were significantly decreased when compared with intact‐side condyles. These differences were not detected 28 d after molar extraction. These findings suggest that occlusal change transiently results in changes in the dynamics of bone metabolism at the mandibular condyles through the downregulation of osteoclastogenesis. These changes may be involved in functional adaptation of the temporomandibular joint.