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In situ fluoride retention and remineralization of incipient carious lesions after the application of different concentrations of fluoride
Author(s) -
Altenburger Markus J.,
Schirrmeister Jörg F.,
Lussi Adrian,
Klasser Manfred,
Hellwig Elmar
Publication year - 2009
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.2008.00585.x
Subject(s) - fluoride , remineralisation , enamel paint , chemistry , dentistry , placebo , tooth remineralization , medicine , inorganic chemistry , alternative medicine , pathology
Limited information is available on the time‐dependent or dosage‐dependent cariostatic efficacy of highly concentrated fluoride compounds. This good clinical practice‐conforming, double‐blind, placebo‐controlled, crossover in situ study tested the hypothesis that a 1.0% amine fluoride fluid is superior to a 0.5% amine fluoride fluid regarding fluoride retention and mineral change in initial caries enamel lesions over a period of 28 d. Fluoride retention was significantly higher after application of the two fluoride fluids compared with placebo but had decreased in both groups to similar levels after only 1 wk. Mineral gain was significantly higher for both verum groups compared with placebo. The use of 1% fluoride fluid resulted in significantly higher remineralization compared with the use of 0.5% fluoride fluid. For both fluoride fluids mineral gain followed a linear relationship with time during the experimental period, indicating a possible further uptake of mineral, even after 4 wk.