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Effects of bisphosphonates on tooth eruption in children with osteogenesis imperfecta
Author(s) -
KamounGoldrat Agnès,
Ginisty Danielle,
Merrer Martine Le
Publication year - 2008
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.2008.00529.x
Subject(s) - osteogenesis imperfecta , medicine , bisphosphonate , dentistry , tooth eruption , orthodontics , osteoporosis , molar , pathology
Bisphosphonates are currently used in the therapy of osteogenesis imperfecta (OI) to decrease the bone fragility observed in OI patients. Bisphosphonate therapy delays tooth eruption in rats. The aim of this study was to determine whether or not bisphosphonate therapy delays tooth eruption in children. The clinical emergence of teeth was observed and the calculated dental age and the number of delayed teeth were determined for 33 OI patients treated with bisphosphonates and for strictly gender‐ and age‐matched controls. There were significant differences between bisphosphonate‐treated patients and controls for calculated dental age and number of delayed teeth. Bisphosphonate therapy was associated with a mean delay of 1.67 yr in tooth eruption in children with OI.