Premium
Interleukin‐17 plays a role in exacerbation of inflammation within chronic periapical lesions
Author(s) -
Čolić Miodrag,
Vasilijić Saša,
Gazivoda Dragan,
Vučević Dragana,
Marjanović Marjan,
Lukić Aleksandra
Publication year - 2007
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.2007.00460.x
Subject(s) - pathogenesis , inflammation , peripheral blood mononuclear cell , exacerbation , interleukin , immunocytochemistry , medicine , interleukin 17 , immunology , lesion , pathology , cd3 , cytokine , in vitro , biology , immune system , cd8 , biochemistry
Interleukin (IL)‐17 plays an important role in inflammation and certain autoimmune diseases. However, its role in the pathogenesis of chronic dental periapical lesions has not been studied. Periapical lesion mononuclear cells (PL‐MNC) were isolated from inflammatory cells and phenotypically analyzed by immunocytochemistry. The cells were cultured in vitro and IL‐17 and IL‐8 were measured in the culture supernatants. Controls were peripheral blood (PB) MNC. The level of IL‐17 and the proportion of neutrophils were significantly higher in symptomatic lesions. In addition, the production of IL‐17 was higher in culture supernatants of PL‐MNC isolated from lesions with a predominance of T cells, and the IL‐17 concentration correlated with the proportion of CD3 + and CD4 + cells. There was a positive correlation between the levels of IL‐17 and IL‐8 in the group of symptomatic lesions. The relationship between these cytokines was additionally confirmed on the basis of augmented production of IL‐8 by both PL‐MNC and PB‐MNC treated with IL‐17. Our results suggest that IL‐17, by stimulating the production of IL‐8, may play a role in exacerbating inflammation within chronic periapical lesions.