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Protective effect of salivary nitrate and microbial nitrate reductase activity against caries
Author(s) -
Doel J. J.,
Hector M. P.,
Amirtham C. V.,
AlAnzan L. A.,
Benjamin N.,
Allaker R. P.
Publication year - 2004
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.2004.00153.x
Subject(s) - nitrate , nitrite , streptococcus mutans , nitrate reductase , nitric oxide , saliva , chemistry , food science , dentistry , microbiology and biotechnology , bacteria , medicine , biochemistry , biology , organic chemistry , genetics
To test the hypothesis that a combination of high salivary nitrate and high nitrate‐reducing capacity are protective against dental caries, 209 children attending the Dental Institute, Barts and The London NHS Trust were examined. Salivary nitrate and nitrite levels, counts of Streptococcus mutans and Lactobacillus spp., and caries experience were recorded. Compared with control subjects, a significant reduction in caries experience was found in patients with high salivary nitrate and high nitrate‐reducing ability. Production of nitrite from salivary nitrate by commensal nitrate‐reducing bacteria may limit the growth of cariogenic bacteria as a result of the production of antimicrobial oxides of nitrogen, including nitric oxide.