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Regeneration of periodontal ligament and cementum by BMP‐applied tissue engineering
Author(s) -
Kuboki Yoshinori,
Sasaki Masaru,
Saito Akira,
Takita Hiroko,
Kato Hiroshi
Publication year - 1998
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1998.tb02176.x
Subject(s) - cementum , periodontal fiber , cementogenesis , regeneration (biology) , dental alveolus , molar , dental cementum , ankylosis , chemistry , dentin , bone morphogenetic protein 2 , dentistry , ligament , clinical attachment loss , anatomy , periodontitis , microbiology and biotechnology , medicine , biology , biochemistry , in vitro
Previously, we demonstrated that the inductive properties of bone morphogenetic protein (BMP) highly depend on the nature of the carrier material used for implantation. In this paper, we show that administration of BMP incorporated in a fibrous collagen membrane can help to regenerate periodontal ligament and cementum both in cat canines and in monkey molars. The partially purified bovine BMP was combined with one or two layers of a fibrous collagen membrane. Although the single layer approach showed partial regeneration of periodontal defects, it also quite often led to ankylosis. The double layer technique in artificially prepared class III furcation defects in monkey molars gave favorable results. After 12 wk, not only the alveolar process but also the periodontal ligament and cementum had regenerated along the entire treated dentin surface. Collagen fibers were arranged more or less perpendicular to the surface of the new cementum. Ankylosis was not seen. It is concluded that the double‐layer approach is superior to the single‐layer technique in regenerating cementum.