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Transforming Growth Factor‐β1 (TGF‐β1) in dentine matrix
Author(s) -
Smith Anthony J.,
Matthews John B.,
Hall Rachel C.
Publication year - 1998
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1998.tb02173.x
Subject(s) - odontoblast , decorin , transforming growth factor , extracellular matrix , receptor , chemistry , matrix (chemical analysis) , immunohistochemistry , microbiology and biotechnology , pulp (tooth) , transforming growth factor beta , dentistry , pathology , biology , medicine , biochemistry , proteoglycan , chromatography
Transforming Growth Factor‐β (TGF‐β) and other members of this family of growth factors have been implicated in tooth development and dental tissue repair. This study aimed to investigate regulatory factors for TGF‐β1 in rabbit incisor dentine matrix and the expression of receptors for TGF‐β in dental tissues better to understand the control of its biological activity. Approximately half of the TGF‐β1 in dentine matrix was present in active form. TGF‐β1 was found in association with latency associated peptide (LAP), betaglycan and decorin in an isolated dentine matrix preparation. Immunohistochemistry showed strong staining for TGF‐β type I and II receptors in odontoblasts with more variable and weaker staining of other pulpal cells. Association of TGF‐β1 with betaglycan, decorin and LAP may regulate the availability and biological activity of this growth factor and influence its presentation to the TGF‐β type I and II receptors on odontoblasts. During dental tissue repair, such control processes will be important in regulating the biological effects of TGF‐β1 on cells of the dentine‐pulp complex.