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Activin and bone morphogenetic protein (BMP) signalling during tooth development
Author(s) -
Heikinheimo Kristiina,
BègueKirn Catherine,
Ritvos Olli,
Tuuri Timo,
Ruch Jean Victor
Publication year - 1998
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1998.tb02171.x
Subject(s) - follistatin , bone morphogenetic protein , activin type 2 receptors , bone morphogenetic protein 10 , acvr2b , bmpr2 , microbiology and biotechnology , bone morphogenetic protein 2 , bone morphogenetic protein 7 , activin receptor , bone morphogenetic protein 8a , receptor , tgf beta signaling pathway , bone morphogenetic protein 5 , biology , transforming growth factor , extracellular , endocrinology , chemistry , in vitro , biochemistry , gene
Activins and bone morphogenetic proteins (BMPs) belong to the transforming growth factor‐β (TGF‐β) superfamily of structurally related cytokines. Results of recent in vivo and in vitro studies suggest that activin A, several BMPs, and their cell surface receptors may participate in tooth development. In addition, follistatin, an extracellular protein that may interact with activin and BMP signaling, appears to be involved. This review focuses on recent advances in relation to the roles of activin/BMP receptors, their ligands and extracellular modifiers during tooth development.