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Dynamic expression of E‐cadherin in ameloblasts and cementoblasts in mice
Author(s) -
Terling C.,
Heymann R.,
Rozell B.,
Öbrink B.,
Wroblewski J.
Publication year - 1998
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1998.tb02166.x
Subject(s) - ameloblast , cementoblast , enamel organ , microbiology and biotechnology , cadherin , cementum , cementogenesis , amelogenin , biology , chemistry , anatomy , enamel paint , pathology , dentistry , cell , dentin , medicine , genetics
During embryonic development, E‐cadherin mediates intercellular adhesion in a variety of epithelia in a spatio‐temporal pattern. We have analyzed the distribution of this cell adhesion molecule in the mouse during odontogenesis, at both mRNA and protein levels, in the mandibular first molars and incisors. E‐cadherin was strongly expressed at the bell stage by the cells of the dental organ, and by the pre‐secretory ameloblasts and the cells of stratum intermedium at the early mineralization stage. At the onset of enamel secretion, E‐cadherin disappeared from the apical pool of the ameloblasts and was later absent from the post‐secretory ameloblasts. E‐cadherin was also found in Hertwig's root sheath and later in the cells producing acellular cementum. These findings indicate that E‐cadherin may be involved in the polarization of the ameloblasts and in the early stages of cementogenesis.