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Age‐dependent changes in insulin‐like immunoreactivity in rat submandibular salivary glands
Author(s) -
Périère Dominique Deville,
Bombara Maria,
Egea JeanChristophe,
Novelli Michela,
Ribes Gérard,
Masiello Pellegrino
Publication year - 1996
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1996.tb00154.x
Subject(s) - submandibular gland , endocrinology , medicine , hormone , paracrine signalling , salivary gland , insulin , senescence , biology , receptor
In recent years, a growing interest had arisen in hormonal factors in salivary glands. We have investigated the changes in the content of an insulin‐like immunoreactive (ILI) compound in the submandibular salivary glands of Sprague Dawley rats during physiological aging, in the range 15 days ‐27 months. The amount of ILI in the submandibular glands of young adult rats was found to be doubled in the post‐natal period until the age of puberty and was maintained in senescence. No significant correlation was found between age‐dependent variations in ILI levels of submandibular salivary glands and circulating insulin concentrations, further supporting previous indications that ILI is being synthesized in situ. It is possible that ILI could exert paracrine effects within the glands, as regards the development of other glandular structures during the first months of life, as well as the preservation of glandular function in senescent animals as well.