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Prevention of etretinate‐induced craniofacial malformations by vitamin B 6 in the rat
Author(s) -
Jacobsson Catharina,
Granström Gösta
Publication year - 1996
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1996.tb00145.x
Subject(s) - etretinate , vitamin , craniofacial , medicine , endocrinology , teratology , intraperitoneal injection , oral administration , dermatology , fetus , biology , pregnancy , genetics , psychiatry , psoriasis
The preventive effect of vitamin B 6 on etretinate‐induced malformations in pregnant Sprague‐Dawley rats was studied. The etretinate‐induced malformation was produced by intraperitoneal administration of 10 mg/kg etretinate at embryonal day 8.5. Vitamin B 6 was administered as intramuscular injections at embryonal day 7.5 and 8.5. Vitamin B 6 reduced the number and severity of facial clefts, micrognatia. meningocele. microtia and blood vessel anomalies. It is suggested that vitamin B 6 induces suppressive effects on etretinate‐induced teratogenesis when administered before or at the same time as the teratogen.