Premium
Antiplaque, antibacterial, and anti‐inflammatory properties of triclosan mouthrinses in combination with zinc citrate or polyvinylmethylether maleic acid (PVM‐MA) copolymer
Author(s) -
Kjaerheim Vibeke,
Skaare Anne,
Barkvoll Pål,
Rölla Gunnar
Publication year - 1996
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1996.tb00137.x
Subject(s) - triclosan , maleic acid , chemistry , polyvinyl alcohol , zinc , antibacterial activity , nuclear chemistry , antibacterial agent , copolymer , antibiotics , bacteria , organic chemistry , biochemistry , medicine , polymer , pathology , biology , genetics
The antibacterial agent triclosan has demonstrated antiplaque and antigingivitis activity in several clinical studies. Retention of antiplaque agents is of significance for their clinical effect. Triclosan has a relatively rapid clearance from the oral cavity, and attempts have been made to increase its oral retention. In the present clinical antiplaque study, it was found that 0.5% copolymer poly‐vinyl‐methylether maleic acid (PVM‐MA) or 0.5% zinc citrate, which are both added to commercial products, inhibited plaque formation to a similar degree when used in combination with 0.3% triclosan, 1.5% sodium lauryl sulfate (SLS) and diluted propylene glycol (PG) in water (1:8). Plaque inhibition was significantly improved compared to a placebo solution. It was shown that these results could not be explained by an increase in antibacterial activity or by a change in the critical micellar concentration. The effect of the same solutions on SLS‐induced inflammation on skin was also tested. It was seen that the triclosan/zinc citrate solution and the control (triclosan/ethanol) decreased the inflammatory response, whereas the solutions containing triclosan in either propylene glycol (PG) or copolymer/PG did not exhibit any anti‐inflammatory capacity.