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Calprotectin levels in oral fluids: the importance of collection site
Author(s) -
Cuida Mihaela,
Brun Johan G.,
Tynning Turid,
Jonsson Roland
Publication year - 1995
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1995.tb00003.x
Subject(s) - calprotectin , medicine , chemistry , disease , inflammatory bowel disease
Calprotectin is a major protein of granulocytes and monocytes with antimicrobial properties, and is released during activation or cell death. In the present stud' the levels of Calprotectin in various oral fluids were analyzed in 12 healthy adults using different collection devices. Parotid saliva, stimulated whole saliva and “mucosal transudate” were collected and analyzed by enzyme‐linked immunosorbent assay (ELISA). The results showed mean concentrations of 3.2, 22.0 and 40.9 mg/l in the respective oral fluids, illustrating great variation of Calprotectin levels between different oral fluids. The results are in accordance with the composition of these saliva samples; the lowest Calprotectin level was obtained in parotid saliva, which contains the purest secretion. These findings illustrate the importance of careful sampling procedures. The levels of salivary calprotectin are markedly influenced by the site of collection.