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Oral retention of glucose at pharmacologically reduced salivary flow in man
Author(s) -
Hase Jan C.,
Birkhed Dowen,
Lagerlöf Folke,
Thornqvist Elisabeth
Publication year - 1994
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1994.tb01176.x
Subject(s) - medicine , dentistry , dermatology
The aim was to study the influence of mouthrinses with glucose, at concentrations ranging from 1 to 50%, on oral retention at two different locations in the oral cavity. Salivary secretion was reduced in 10 subjects by injection of methylscopolamine nitrate submucosally. The volunteers were randomly assigned to rinse with 10 ml of either 1%, 10%, or 50% glucose solution for 30 s, after which measurements of glucose concentration and parotid salivary secretion rate were performed during a 10‐min period. The results showed higher salivary glucose levels vestibularly than sublingually. The difference in glucose retention between the two locations increased when the salivary flow rate recovered. The relationship between secretion rate and area under the curve for glucose measured sublingually, but not in the vestibule, was bilinear.