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Effect of fluoride on caries progression and dentin apposition in rats fed on a cariogenic or non‐cariogenic diet
Author(s) -
Kortelainen Sinikka,
Larmas Markku
Publication year - 1993
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1993.tb01639.x
Subject(s) - dentin , apposition , fluoride , chemistry , sucrose , odontoblast , dentinogenesis , dentistry , enamel paint , dentinal tubule , food science , medicine , inorganic chemistry
The effect of fluoride in drinking water on the progression of dentinal caries and dentin apposition was studied in Wistar rats. The initiation of enamel caries lesions was first induced for 2 wk with S. sobrinus and a 43% sucrose diet after weaning. Thereafter the animals were fed on either a cariogenic or a non‐cariogenic diet and distilled water supplemented with 0, 1, 7 or 19 ppm fluoride. The areas of dentinal caries and dentin apposition were quantified after tetracycline staining. Fluoride reduced dentinal caries progression after the initiation of lesions in the presence of a cariogenic diet at a concentration of 19 ppm F, and without sucrose at 1 ppm F. The effect of fluoride in reducing dentin apposition with a cariogenic diet was dose‐dependent, whereas fluoride in non‐cariogenic groups had practically no effect on dentin formation. These results suggest that fluoride together with a high concentration of sucrose in the diet might have an odontoblast‐mediated effect on the regulation of the progression of dentinal caries.