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Dentin formation in miniature pigs with special reference to indomethacin and orthodontic treatment
Author(s) -
Giunta Daniela,
Keller Johnny,
Nielsen Frank Farsö,
Melsen Birthe
Publication year - 1993
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1993.tb01116.x
Subject(s) - dentin , mineralization (soil science) , dentistry , chemistry , tetracycline , orthodontics , medicine , biochemistry , antibiotics , organic chemistry , nitrogen
The rate of dentin mineralization and the influence of indomethacin on the dentin mineralization rate during orthodontic treatment was determined in miniature pigs by intravital labeling with tetracycline. The results demonstrated that the dentin mineralization rate in the control animals was 3.8 μm/day, a rate corresponding to that of human teeth. Both indomethacin and orthodontics had an effect on the dentin mineralization rate, indomethacin reducing and orthodontic forces increasing it. In combination, the two factors neutralized each other.