Premium
Alveolar ridge augmentation in rats by combined hydroxylapatite and osteoinductive material
Author(s) -
PINHOLT ELSE MARIE,
BANG GISLE,
HAANAES HANS REIDAR
Publication year - 1991
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1991.tb01025.x
Subject(s) - hydroxylapatite , dentin , dentistry , alveolar ridge , connective tissue , dental alveolus , implant , foreign body giant cell , radiodensity , chemistry , anatomy , biomedical engineering , pathology , medicine , surgery , radiography , biochemistry , enzyme
— The purpose of this study was to examine if increased bony ingrowth developed when hydroxylapatite was implanted together with an osteoinductive substrate. Dense hydroxylapatite granules (HA) (Calcitite, Calcitek, San Diego, CA, USA) were mixed with equal volumes of allogenic, demineralized, lyophilized dentin or bone and implanted subperiosteally for alveolar ridge augmentation purposes and heterotopically in the abdominal muscles in rats. Light microscopic evaluation revealed that HA was surrounded by fibrous connective tissue containing foreign body giant cells and it had neither an osteoinductive nor an osteoconductive effect. The newly formed bone induced from the implanted allogenic, demineralized, lyophilized dentin or bone was never found in close contact with the HA and did not incorporate the implant.