Premium
Antibacterial activity of dental gels containing combinations of amine fluoride, stannous fluoride, and chlorhexidine against cariogenic bacteria
Author(s) -
OSTELA ILKKA,
TENOVUO JORMA
Publication year - 1990
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1990.tb00933.x
Subject(s) - fluoride , chlorhexidine , chemistry , bacteria , nuclear chemistry , dentistry , antibacterial activity , amine gas treating , organic chemistry , inorganic chemistry , medicine , biology , genetics
– The in vitro susceptibility of Streptococcus mutans, S. sobrinus and Lactobacillus casei to dental gels containing various combinations of amine fluoride (AmF 297), stannous fluoride (SnF 2 ), and chlorhexidine (CHX) was studied. The combination of AmF‐SnF 2 with a total fluoride content of 1.2% was the most effective against mutans streptococci but not against L. casei. At notably lower total fluoride concentration (0.4%), AmF as such or combined with SnF 2 , was significantly less effective against mutans streptococci than CHX or CHX‐AmF‐SnF 2 combinations. CHX‐AmF combination was a slightly more potent inhibitor of streptococcal growth than CHX‐NaF. With L. casei the differences between various gels were small but CHX alone seemed to be the most effective. Of the studied agents, CHX seemed to be the most potent individual chemotherapeutic compound whose activity against S. mutans could be enhanced by combining it with AmF. However, clinical experiments are required to test the in vivo antibacterial efficacy of CHX‐AmF and AmF‐SnF 2 combinations which were most effective in our in vitro experiments.