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Effects of irradiation with dental light curing units on Langerhzuis cells in human stratified epithelium in heterotransplanted skin
Author(s) -
BONDING NINA,
GRAEM NIELS,
RYGAARD JÖRGEN,
DABELSTEEN ERIK
Publication year - 1987
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1987.tb01961.x
Subject(s) - epithelium , irradiation , chemistry , immunofluorescence , human skin , stratified squamous epithelium , pathology , materials science , medicine , antibody , biology , immunology , physics , nuclear physics , genetics
– Grafts of human skin on nude mice were subjected to a single dose of either 2 1 / 2 min or 4 min of radiation from two different commercial dental light curing units with emission mainly in the visible light spectrum but also with a small fraction of UV‐A light. Seventy‐two hours after exposure the tissue was examined for presence of Langerhans cells using monoclonal antibody OKT6 double layer immunofluorescence staining. Epithelial hyperplasia and reduced reactivities for OKT6 were seen after 2 1 / 2 min exposure. After 4 min of exposure OKT6 positive ceils were completely absent from the epithelium. The results indicate that emission from dental light curing units can affect Langerhans cells in human epithelium and could thus modify the local immunologic response.