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Cytotoxic effects of cobalt‐chromium alloys on fibroblasts derived from human gingiva
Author(s) -
ARVIDSON KRISTINA,
COTTLERFOX MICHELE,
HAMMARLUND ERNA,
FRIBERG ULF
Publication year - 1987
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1987.tb01853.x
Subject(s) - cobalt , chromium , nickel , metallurgy , chemistry , toxicity , metal , nuclear chemistry , materials science , organic chemistry
Abstract – The in vitro toxicity of 15 different cobalt‐chromium alloys used in removable partial dentures and dental implants was studied. The composition of the alloys was determined by X‐ray spectrometry. Alloys were tested on human oral fibroblasts in low density, semiconfluent or confluent cultures. The cultures were observed in a phase contrast microscope over a period of 3 wk. The alloys could be divided into three groups depending upon the degree of cell injury evoked. Group I alloys caused no cell injury. Group II alloys caused slight to moderate cell injury seen first after 3–7 days of exposure. Group III alloys caused severe cell injury with signs of cell damage detected after 12 h and total ceil death after 3–14 days. The alloys' composition varied considerably with regard to cobalt, chromium and nickel as well as other components. Nevertheless, group II and III alloys had a higher nickel content than group I alloys in general.