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In vitro studies of monocyte function in two siblings with Papillon‐Lefèvre syndrome
Author(s) -
PREUS HANS R.,
MÖRLAND BERIT
Publication year - 1987
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1987.tb01394.x
Subject(s) - phagocytosis , monocyte , in vitro , immune system , immunology , macrophage , chemistry , biology , medicine , genetics
— Blood monocytes were isolated from two siblings with Papillon‐Leferve syndrome (PLs) and compared to corresponding cells from their healthy cousin. The number ofmonocytes isolated were within normal limits in all three test participants. Aggregating tendency was increased when PLs monocytes were cuitured in ihe presence of autologous sera. The monocyre ability or specific immune phagocytosis was decreased in PLs patients. The mnonocyte marphology, non‐specilic phagocytosis, lysosomal enzyme activities, and response to E. coli endo‐toxin were similar in patients and control.