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Macrophage colonization of infected and noninfected dental tissues in vitro
Author(s) -
WEDENBERG CECILIA,
LINDSKOG SVEN
Publication year - 1986
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1986.tb01769.x
Subject(s) - mineralized tissues , dentin , in vitro , resorption , chemistry , macrophage , incubation , endogeny , enamel paint , microbiology and biotechnology , pathology , biology , dentistry , biochemistry , medicine
— Attachment and spreading of phagocytes on a mineralized tissue surface is crucial for their proper resorptive function. In other studies, attachment and spreading have been shown to be highly dependent on the nature and composition of the surface. In the present study, peritoneal macrophages were cultured on infected and non‐infected mineralized and non‐mineralized dental tissues, which were examined with scanning electron microscopy at different observation periods. Although some cells had attached to non‐infected predentin, only a few showed signs of spreading, even after long incubation times. This contrasted with the behavior of macrophages cultivated on enamel, mineralized dentin and infected predentin. Most of these cells showed spreading and the characteristics of active, phagocytosing cells. The reluctance of macrophages to spread on non‐infected predentin was suggested to be due to the non‐mineralized nature of this tissue, although an influence of endogenous resorption inhibitors cannot be excluded.