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Studies on the whole‐body distribution of 14 C‐trithioparamethoxyphenylpropene in mice
Author(s) -
ISACSSON GÖRAN,
SINGER PETER
Publication year - 1985
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1985.tb01953.x
Subject(s) - kidney , placenta , endocrinology , fetus , distribution (mathematics) , medicine , secretion , urinary system , urinary bladder , chemistry , biology , pregnancy , mathematical analysis , mathematics , genetics
– The study was undertaken to map the whole body distribution of trithioparatnethoxyphenylpropene, TPMPP, a substance which is believed to stimulate salivaty secretion. Two series of male and pregtiant female mice were given 4.3 μCi 14 C‐TPMPP by gastric intubation. The animals were sacrificed at various intervals, embedded in CMC and frozen. Sections were taken from all levels and wholebody autoradiography performed. Four hours after administration the isotope was located in the intestines, liver, gall bladder, kidney and urinary bladder. High concentrations of the isotope persisted for 12 h with the exception of the kidney which showed decreasing concentrations after 4 h. The isotope was not found in the fetus or placenta. 24 h after administration no activity could be detected in any of the above mentioned organs. If TPMPP plays a role in salivary secretion this must be secondary as it was not found in the salivary glands, or nerve structures.