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Subpopulations of lymphocytes in connective tissue from phenytoin‐induced gingival overgrowth
Author(s) -
DAHLLÖF GÖRAN,
MODÉER THOMAS,
OTTESKOG PER,
SUNDQVIST KARLGÖSTA
Publication year - 1985
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1985.tb01348.x
Subject(s) - phenytoin , connective tissue , medicine , pathology , epilepsy , psychiatry
– The presence of mononuclcar cells was studied in gingival biopsies from seven children exhibiting phenyloin(PHT)‐induced gingival overgrowth, three children with gingivitis and a control group consisting of three children without clinical signs of inflammation. The mononucle‐ar cells were detected using monoclonal antibodies defining functional T‐lymphocytc subpopulations, B‐lymphocytes and monocytes. Gingival biopsies from the individuals in the PHT‐group showed a substantial number of mononuclear cells. The distribution of mononuclear cells in separate individuals were as follows: 69‐95% OKT3 +/Leu4+ cells (T‐lymphocytes), 50‐64% OKT4 +/Leu3 + cells (T‐helper phenotype) and 29‐46% OKT8 + cells (T‐suppressor/cytotoxic phenotype). None of the biopsies in the PHT‐group contained more than a few scattered plasma cells. The vast majority of all mononuclear cells present in the biopsies reacted with OKIal, a monoclonal antibody defining the HLA‐DR framework. In contrast, biopsies from the control group and the gingivitis group contained few mononuclear cells, the majority of which were T‐cells. This suggests that immunologic reactions mediated by T‐cells may play a role in the pathogenesis of the PHT‐induced lesion.