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Inactivation of guinea‐pig serum proteinase inhibitors by Bacteroides gingivalis
Author(s) -
HERRMANN BJÖRN F.,
CARLSSON JAN,
SUNDQVIST GÖRAN K.
Publication year - 1985
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1985.tb01324.x
Subject(s) - guinea pig , bacteroides , trypsin , microbiology and biotechnology , bacteroidaceae , enzyme , proteinase k , biology , chemistry , bacteria , biochemistry , endocrinology , genetics
– The activity of proteinase inhibitors of guinea‐pig serum was evaluated by using trypsin as test enzyme. Strains of black‐pigmcnted Bacteroides species were incubated with serum under anaerobic conditions. Strains of Bacteroides gingivalis inactivated the trypsin inhibitors of guinea‐pig serum within 1 h, while the other strains reduced the activity of the trypsin inhibitors by less than 50% within 48 h. The inactivation of proteinase inhibitors of guinea‐pig serum by B. gingivalis may be an important pathogenic mechanism in the spreading necrotic infections induced in guinea pigs by pure cultures of this species.