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Benign mucous membrane pemphigoid with linear IgA deposits in oral mucosa
Author(s) -
HIETANEN JARKKO,
RANTALA IMMO,
REUNALA TIMO
Publication year - 1985
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1985.tb01307.x
Subject(s) - dapsone , oral mucosa , immunoglobulin a , buccal mucosa , pathology , mucous membrane , medicine , direct fluorescent antibody , lamina lucida , immunoelectron microscopy , antibody , immunofluorescence , dermatology , cicatricial pemphigoid , pemphigoid , immunoglobulin g , oral cavity , bullous pemphigoid , immunology , immunohistochemistry , ultrastructure , dentistry , basal lamina
– Two patients with severe oral ulcerations and concomitant lesions in the nose, eyes and genitals were examined. The immunofluorescence (IFL) studies of buccal and genital mucosa revealed that the only deposited immunoglobulin was IgA. Immunoelectron microscopy confirmed the linear pattern of IgA deposition and localized IgA in lamina lucida in both patients. Dapsone 50 mg daily was effective in controlling the disease activity partially in the first and completely in the second patient. The results suggest that our patients had benign mucous membrane pemphigoid (BMMP) with linear IgA deposition but do not exclude a mucosal form of a newly recognized bullous skin disease termed linear IgA disease.