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Peptidergic nerves in human tooth pulp
Author(s) -
GRÖNBLAD MATS,
LIESI PÄIVI,
MUNCK ANNE MARIE
Publication year - 1984
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1984.tb00898.x
Subject(s) - substance p , pulp (tooth) , ground substance , neuropeptide , toothache , anatomy , chemistry , enkephalin , dentistry , medicine , pathology , opioid , receptor , connective tissue
– Substance P‐like and enkephalin‐like immunoreactive nerve fibers were observed in the human tooth pulp. Immunoreactivity for substance P could be demonstrated in thin, beaded nerve fibers and glomerular‐type nerve structures both in the center and in more peripheral parts of the tooth pulp. Substance P‐like nerve fibers predominated in the center of the pulp substance, while a thicker type of enkephalin‐like nerve fibers were more commonly seen at the periphery of the pulp. Controls exhibited no immunoreactivity for either neuropeptide. It is tentatively suggested that a dual innervation by substance P‐like fibers and enkephalin‐like nerve fibers may be involved in the mediation of toothache in man.