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Increased luminol enhanced chemi‐luminescence from peripheral granulocytes in juvenile periodontitis
Author(s) -
ÅSMAN BJÖRN,
ENGSTRÖM PERERIK,
OLSSON THOMAS,
BERGSTRÖM KURT
Publication year - 1984
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1984.tb00882.x
Subject(s) - phagocytosis , luminol , opsonin , chemiluminescence , bacteria , pathogenesis , granulocyte , chemistry , immunology , microbiology and biotechnology , medicine , biology , chromatography , genetics
– The granulocyte function in patients with juvenile periodontitis (JP) (eight men and six women, aged 13–33 yr) and sex and age matched controls was determined by the luminol enhanced chemiluminescence (CL) induced by opsonized and unopsonized bacteria or latex beads. Maximal CL induced by latex beads with or without autologus serum did not differ between the two groups. However, bacteria with or without autologous serum seemed to induce a higher maximal CL in the JP group. The difference was statistically significant for the results obtained with opsonized bacteria. Serum opsonized bacteria induced a much higher maximal CL than the unopsonized. The opsonin dependent reaction indicates a close association with the process of phagocytosis. The increased CL of granulocytes in JP could indicate the formation of extracellularly free oxygen radicals with the potential to damage tissue. These observations support a possible involvement of the granulocytes in the pathogenesis of JP.