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Some aspects of the dynamics of Cu and Zn retained in plaque as related to their effect on plaque pH
Author(s) -
AFSETH JOHN
Publication year - 1983
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1983.tb00797.x
Subject(s) - chemistry , copper , zinc , dental plaque , metal , nuclear chemistry , mouth rinse , salt (chemistry) , metal ions in aqueous solution , neutron activation analysis , dentistry , radiochemistry , medicine , organic chemistry
– The effect of glucose on acid production in dental plaque was measured in vivo after oral rinses with CuSO 4 (1.0 mM) or Zn (Ac) 2 (20 mM) and compared with the retention of the metals. Plaque samples were analyzed for copper and zinc by neutron activation analysis. A rinse with the copper salt solution significantly depressed acid formation in plaque for a period of 6 h whereas a rinse with the zinc solution was effective for 2 h. Plaque concentrations of the metals increased from less than 75 p.p.m. to more than 1000 p.p.m. 2 h after a rinse with the metal salts. Twelve hours after a rinse the mean plaque concentrations were 190 p.p.m. Cu or 358 p.p.m. Zn respectively. Reducing the pH of the copper sulfate solution from 5.7 to 2.0 yielded lower Cu concentrations in plaque 2 h after a rinse, indicating lower initial retention. The results clearly demonstrate a high and long lasting retention of metal ions in dental plaque and their biological effect in this environment.