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Arrestment of caries in rats by adding fluoride and magnesium to the diet
Author(s) -
LUOMA ANJARIITTA,
KOSKINEN MAARIT,
LUOMA HEIKKI
Publication year - 1983
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1983.tb00787.x
Subject(s) - weanling , magnesium , fluoride , enamel paint , dentin , phosphorus , food science , chemistry , casein , sugar , sucrose , positive control , composition (language) , dentistry , zoology , biology , medicine , endocrinology , traditional medicine , inorganic chemistry , linguistics , organic chemistry , philosophy
– 90 weanling Osborne‐Mendel rats were divided into six groups of 15 animals each. Half of them received a modified MIT 200 control diet in which one third of the sucrose of the original formula was replaced by high‐extraction wheat flour, magnesium content reduced to 360 parts/10 6 and phosphorus content increased with NaH 2 PO 4 2H 2 O to 0.49%. For the experimental diet, an additive containing 75 parts/10 6 fluoride (as NaF) and 50 parts/10 6 magnesium (as MgO) was mixed into the above composition. Each diet was given to three experimental or three control groups for 25, 40, or 55d. Caries involving dentin‐enamel junction was significantly reduced through the F + Mg addition by 37%, 51%, and 61% on the 25th, 40th, and 55th day, respectively. Caries involving dentin was significantly reduced by 58%, 68%, and 70%, respectively. Caries arrestment was observable in both the control rats and rats fed the F + Mg additive but in the latter animals the reduction meant an arrestment at a lower level than in controls. This arrestment resembles an early caries arrestment obtained recently in a clinical trial by fluoridation of dietary sugar products. The growth of the animals was only temporarily retarded by the additives.