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Qualitative changes in saliva composition after short‐term administratio of imipramine and zimelidine in healthy volunteers
Author(s) -
KNORRING LARS,
MÖRNSTAD HAKAN
Publication year - 1981
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1981.tb01688.x
Subject(s) - saliva , imipramine , chemistry , fucose , sialic acid , composition (language) , medicine , pharmacology , endocrinology , biochemistry , glycoprotein , alternative medicine , pathology , linguistics , philosophy
– Ten healthy volunteers participated in a double‐blind, controlled, randomized, cross‐over trial, where the effects of te antidepressan: drugs imipramine (75 mg/day) and zimelidine (100 mg/day and 200 mg/day) on saliva secretion rate and saliva composition were tested. The saliva secretion decreased and qualitative changes were found. Imipramine (75 mg/day) and zimelidine (200 mg/day), but not zimelidine (100 mg/day), increased buffer capacity and the components of the salivary glycoproteins (sialic, fucose, hexoses). Total proteins, amylase, secretory component and electrolytes (Na + , K + , Ca ++ , PO 4 3‐ ) did not change significantly.