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Effect of cyclophosphamide on dentinogenesis in the rat incisor: fluorescence microscopic and microradiographic investigations
Author(s) -
KOPPANG HABBA STRÖMME
Publication year - 1981
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1981.tb01278.x
Subject(s) - calcein , dentin , dentinogenesis , pulp (tooth) , dentistry , incisor , apposition , chemistry , medicine , anatomy , biochemistry , odontoblast , membrane
— Previousy described dentin reactions to cyclophosphamide (CPhA) were studied by means of fluorescent labeling and microradiography. Ten adult rats received 20mg/kg calcein i.p. on days 0, 4,7 and 10, and 40mg/kg CPhA 30 min after the first calcein injection. Two animals served as controls. the observation time was 14 d. Fluorescence microscopy and microradiograsphy of the maxillary incisors revealed 1) Neche‐like defects in dentin starting tomineralize 1‐4 d after the CPhA administration labially, while lingually the niches developed later and were completed earlier,2) localized reduced and increased growth lingually,3) continuous but reduced apposition of a hyponmineralized dentin in the niches, and 4) niche osteodentin produced by pulp cells.