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Effects of 2‐deoxy D‐glucose and other sugar analogues on acid production from sugars by human dental plaque bacteria
Author(s) -
ROBERTS K. R.,
HAYES M. L.
Publication year - 1980
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1980.tb01215.x
Subject(s) - dental plaque , sugar , bacteria , sweetening agents , chemistry , biochemistry , food science , microbiology and biotechnology , biology , genetics
– Solutions (10–25 μM) of D‐glucose, N‐acetyl‐D‐glucosamine, D‐fructose, sucrose, maltose, lactose and maltotriose were readily metabolised to acid (140–250 μmol H + wet g −1 h −1 ) by anacrobic suspensions of fresh plaque at pH 7.5. D‐Mannose, D‐galactose, D‐glucosamine and trehalose were broken down more slowly (35–115 μmol H + wet g −1 h −1 ). Inhibition of this acid production occurred on adding excess amounts of 2‐deoxy‐D‐glucose or 5‐thio‐D‐glucose. Similarly, excess amounts of cellobiose specifically inhibited acid liberation from lactose. No acid production was detected from a number of other sugars and sugar derivatives, some of which may be useful sucrose substitutes.