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Long‐term effects of colchicine on dentinogenesis in rat incisors
Author(s) -
NOGUEIRA TEREZINHA DE OLIVEIRA,
STENE TORBJØRN,
KOPPANG HANNA STRØMME
Publication year - 1980
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1980.tb00714.x
Subject(s) - odontoblast , dentinogenesis , dentin , dentinal tubule , colchicine , chemistry , dentistry , cingulum (brain) , anatomy , orthodontics , biology , medicine , fractional anisotropy , magnetic resonance imaging , white matter , radiology
– Colchicine in doses of 0.5, 1.0 and 1.5 mg/kg was administered to 15 rats divided in three experimental groups. Histomorphologic investigation of the maxillary incisors after 2 weeks revealed; 1) alterations in the odontoblasts mainly related to size, shape, polarity and staining properties, and 2) presence of irregular dentin separated from normal dentin by one or two incremental lines. The dentinal irregularities were dose‐dependent and consisted of twisting of the dentinal tubules, globular formations and cellular inclusions in addition to niche‐like defects.