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Short‐term reactions of human dental pulp to formocresol and its components – a clinical‐experimental study
Author(s) -
MEJàRE INGEGERD,
LARSSON ÅKE
Publication year - 1979
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1979.tb00691.x
Subject(s) - pulpotomy , pulp (tooth) , formaldehyde , dentistry , fixation (population genetics) , in vivo , chemistry , pulpitis , medicine , biology , biochemistry , microbiology and biotechnology , gene
– Pulps of 58 human premolars were amputated under standardized conditions, and standardized amounts of dressings containing 4 or 19% formaldehyde solutions, 35% cresol or formocresol, were applied to the wound surface. Tissue reactions were studied after 4, 8 or 16 d using enzyme histochermical and routine histologic techniques. The results showed that formaldehyde fixed the tissue in vivo , the extent of fixation being dependent on the concentration of formaldehyde. Fixation did not reach the apical foramen. Formaldehyde also caused vascular changes at varying distances from the fixed tissue, indicating transport of formaldehyde via the vessels, Cresol caused necrosis and vascular changes limited mainly to the upper portion of the root pulp. Application of formocresol resulted in devitalization of the whole or almost the whole of the root pulp within 4 d, accompanied by complex vascular changes, depending mainly on the formaldehyde component. Root pulp exposed to formocresol for 5 min only showed partial devitalization due to compromised blood flow, while practically no fixation occurred. The inflammatory response to formocresol and its components was remarkably limited.