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Autoradiography of 90 Sr in developing rats
Author(s) -
OLSEN INGAR,
JONSEN JON
Publication year - 1979
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1979.tb00663.x
Subject(s) - dentin , enamel paint , pulp (tooth) , chemistry , intraperitoneal injection , dentistry , crown (dentistry) , anatomy , radiochemistry , medicine , biology
— The distribution patterns of 90 Sr in five littermate. 8‐day‐old Wistar rats were studied by whole body autoradiography. Rats were killed 15 min, I, 4, 24, and 72 h after a single intraperitoneal injection of the isotope. Immediately after administration, 90 Sr was distributed throughout most of the soft tissues of the body. The soft tissue deposits had practically disappeared after 4 h. In the hard tissues of the body, 90 Sr accumulated up to 24–72 h. Fifteen minutes after injection the uptake of 90 Sr in the enamel of the teeth was highest in the occlusal and incisal regions. 90 Sr gradually accumulated throughout the enamel and after 72 h its distribution in this layer was fairly uniform. Immediately after injection a narrow zone of radioactivity appeared in the dentin near the pulp. This zone broadened with time towards the dentinoenamel junction and included the entire dentin layer 72 h after injection. Initially, the uptake of 90 Sr was higher in the dentin than in the enamel, particularly in the cervical areas of the crown. This difference became less apparent with time. There was good correlation between the uptake in teeth and bones, supporting the use of teeth as indicators of the 90 Sr body burden.