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Determination of fluoride and chlorhexidine from chlorhexidine/fluoride‐containing dentifrices
Author(s) -
DOLLES OVE K.,
BONESVOLL PER,
CAMST OLAV N.,
GJERMO PER
Publication year - 1979
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1979.tb00662.x
Subject(s) - chlorhexidine , fluoride , dentifrice , chemistry , dentistry , nuclear chemistry , medicine , inorganic chemistry
Abstract— The intention of the present experiment was to study the effects of a possible interaction between fluoride and chlorhexidine when both agents were incorporated in the same vehicle. The amount of fluoride extractable from dentifrices containing 0.1% NaF and the fluoride ion activity were not reduced by the addition of 2% chlorhexidine digluconate. Less than 50% of the added chlorhexidine was available when the dentifrices were dissolved in deionized water. This was not affected by the presence of fluoride. The in vitro antibacterial activity of the chlorhexidine‐containing dentifrices was not reduced by the addition of fluoride. Approximately 40% of the chlorhexidine was retained in the human oral cavity after brushing for 1 min with both the chlorhexidine‐ and the chlorhexidine fluoride‐containing dentifrice. Thus the binding of chlorhexidine to vehicle ingredients when dissolved in water is probably too weak to affect the retention in the mouth.