Premium
Effect of vincristine on odontoblasts in rat incisor
Author(s) -
Stene Torbjörn
Publication year - 1978
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1978.tb00637.x
Subject(s) - odontoblast , vincristine , pulp (tooth) , population , chemistry , ameloblast , incisor , dentin , mitosis , anatomy , pathology , dentistry , enamel paint , medicine , microbiology and biotechnology , biology , chemotherapy , environmental health , cyclophosphamide
— Vincristine in doses of 0.1, 0.3, 0.5 and 0.7 mg/kg was administered to 60 rats in four groups. Histomorphologic investigation of the odontoblast population in the maxillary incisors revealed dose‐dependent reactions consisting of (1) swelling of the odontoblasts and an accumulation of abnormal mitotic cells in the germinative parts of the pulp after 5 h, (2) a supervening necrosis and destruction of some odontoblasts and of the mitotic cells after 24 h, and (3) after 3 d, a reversal to normal structure in some parts of the odontoblast population, but a further development of the vincristine‐induced changes, with severe cellular derangement and irregular predentin production, in others.