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Effect of experimental neutropenia on oral wound healing in guinea pigs
Author(s) -
ANDERSEN L.,
ATTSTRÖM R.,
FEJERSKOV O.
Publication year - 1978
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1978.tb00624.x
Subject(s) - neutropenia , wound healing , heterologous , medicine , guinea pig , oral cavity , pathology , immunology , biology , surgery , dentistry , chemotherapy , biochemistry , gene
— The influence of experimental neutropenia on the wound healing process in standardized excisional palatal wounds was studied in 16 guinea pigs. Corresponding wounds in 15 normal animals were used as controls. Neutropenia was induced and maintained by daily injections of heterologous anti‐neutrophil serum. One‐micron sections from biopsies of palatal mucosa sampled 6, 24, 48 and l20h after wounding were evaluated with special reference to the progress of epithelial wound repair and to the occurrence and location of inflammatory cells and bacteria. In animals treated with antiserum, neutrophilic leukocytes disappeared from the wound cavity, whereas other inflammatory cells remained unchanged. Further bacterial invasion deep into the cavity was observed. The epithelial repair took place at a deeper level in the wounds of neutropenic animals compared with those of normal animals. The rate of re‐epithelialization was the same in neutropenic and control wounds. The experiment indicates that the neutrophils in oral wounds provide a principal agency for host defense against microorganisms and probably thereby indirectly determine the direction and level of epithelial cell migration.