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Prolonged in vitro closure of the mouse secondary palate by salicylates
Author(s) -
SAXEN IRMA
Publication year - 1975
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1975.tb00429.x
Subject(s) - sodium salicylate , in vivo , in vitro , secondary palate , closure (psychology) , organ culture , homologous chromosome , chemistry , dentistry , medicine , biology , pharmacology , anatomy , biochemistry , genetics , gene , economics , market economy
— In organ culture sodium salicylate and acetylsalicylic acid in a 1.4 mM concentration caused prolongation of the time needed for the closure of the mouse secondary palate. The response of Strain A and the hybrids CBA×A was more distinct than that of Strain CBA. The mitotic rate, calculated from serial sections, was significantly reduced in the salicylate‐treated palatal shelves in both strains. The extrapolation of the results to an in vivo situation is discussed in the light of different theories of the mechanism of cleft palate formation.