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Papain‐induced changes in the cranial base of rats
Author(s) -
SGHRAMM J. E.,
MELSEN B.,
LA COUR S.
Publication year - 1974
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1974.tb01922.x
Subject(s) - papain , saline , skull , anatomy , endocrinology , medicine , biology , biochemistry , enzyme
– Alterations of the cranial base induced by parenterally administered papain were studied on rats by means of a new microradiographie technique. The material consisted of 28 males and 36 females, randomly divided into one papain injected group and one saline injected. The experiment started when the rats weighed 90 ± 5 g, and daily injections were given for 12 d. Differences between experimental and sham‐operated animals were most pronounced in the males. Apart from the length of the presphenoid bone, all measurements in males were reduced, whereas in females only the total length of the skull, nasal length and length of the basisphenoid bone were significantly smaller in the papain than in the saline injected animals. The influence of papain on angular measurements was also greater in males than in females, akhough the type of alterations found was the same. It is suggested that the alterations are caused by changes in the degree of differentiation in synchondral growth.