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The importance of zinc to cell proliferation in endochondral growth sites in the white rat
Author(s) -
BERGMAN BO,
FRIBERG ULF,
LOHMANDER STEFAN,
ÖBERG TORSTEN
Publication year - 1972
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1972.tb00317.x
Subject(s) - endochondral ossification , zinc , cell growth , condyle , thymidine , medicine , endocrinology , chemistry , cell , biology , anatomy , andrology , biochemistry , cartilage , in vitro , organic chemistry
– The possible importance of zinc to cell proliferation in endochondral growth sites in the white rat was studied using zinc‐deficient feeding and light microscopic autoradiography with tritiated thymidine. Eight experimental rats were given a zinc‐deficient diet ad libitum and eight paired‐fed controls were given the same diet plus zinc supplement. After 3 weeks on the experimental diet, at which time the animals were 6 weeks old, they were injected with H 3 ‐thymidine. Two rats from each group were killed after 1 h, and 1, 3 and 6 d. Tissue specimens were taken from the mandibular condyle, the proximal epiphysis of the humerus and the costo‐chondral junction of the rib. The autoradiographs indicated a reduction, as compared to the control rats, of cell proliferation in the three endochondral growth areas in the experimental rats.