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Effectivity of a new local analgesic Hoe 40 045
Author(s) -
WINTHER J. E.,
NATHALANG B.
Publication year - 1972
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1972.tb00291.x
Subject(s) - mepivacaine , analgesic , anesthesia , lidocaine , medicine , dentistry
– A new local analgesic, temporarily named Hoe 40 045, was investigated in two double‐blind studies, using lidocaine and mepivacaine for comparison. Groups of dental students, aged 20–32 years, received under standardized conditions an injection of 1 ml of each solution at the maxillary lateral incisor. Vitality tests were performed at regular intervals with a Bofors pulp tester. Eight different solutions were tested, Hoe 40 045 was supplied in 2 % and 4 % solutions, lidocaine in a 2 % solution and mepivacaine in a 3 % solution, all with and without adrenaline (5 μg/ml). Hoe 40 045 showed, in both concentrations with vasoconstrictor added, excellent results regarding frequency, duration and extent of analgesia. The solutions without adrenaline were not able to produce satisfactory and reliable dental analgesia. It was concluded that Hoe 40 045 2%– adrenaline (5 μg/ml) with a frequency of analgesia close to 100, a duration of analgesia of 43 min and a latency period of 3 min could be a valuable local analgesic in dental practice. The 4% solution with adrenaline (5 μg/ml) showed slightly better results especially regarding duration of analgesia (55 min). However, this long duration, which for most dental procedures is unneccessary, does not justify a 100% increase in concentration of the active component.