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Prognostic significance of Ki‐67 in salivary gland carcinomas
Author(s) -
Larsen Stine Rosenkilde,
Bjørndal Kristine,
Godballe Christian,
Krogdahl Annelise
Publication year - 2012
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2012.01148.x
Subject(s) - ki 67 , salivary gland , grading (engineering) , univariate analysis , pathology , medicine , pathological , stage (stratigraphy) , immunohistochemistry , proliferative index , subtyping , gastroenterology , multivariate analysis , oncology , biology , ecology , paleontology , computer science , programming language
J Oral Pathol Med (2012) 41 : 598–602 Background: Salivary gland carcinomas are a heterogeneous group of tumors with varying malignant potential. In this study, we evaluated the proliferative marker Ki‐67 in salivary gland carcinomas and related the Ki‐67 index to clinical data. Methods: A total of 176 salivary gland carcinomas of 13 different subtypes were stained immunohistochemically for Ki‐67. The number of Ki‐67 positive cells was counted and the Ki‐67 index was calculated as the percentage of positive tumor cells. Results: The Ki‐67 median value was 26 (range 1–99). The median follow‐up time was 6.9 years (range 0–19 years). The 5‐ and 10‐year crude survival was 70% and 59%, respectively. In univariate analysis, Ki‐67 index, stage, vascular invasion and tumor grade were significantly related to crude survival, but in multivariate analysis only Ki‐67 index, age, and stage were independent prognostic factors. Conclusion: We showed that irrespective of subtyping, grading or morphological appearance of tumor, the Ki‐67 index is an important and independent prognosticator. Clinical and histo‐pathological data must be considered, when planning the treatment of the individual patient. We have shown that besides stage and age of the patient, Ki‐67 is a strong, independent prognostic factor.