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Prognostic significance of matrix metalloproteinase‐2, ‐8, ‐9, and ‐13 in oral tongue cancer
Author(s) -
Mäkinen Laura K.,
Häyry Valtteri,
Atula Timo,
Haglund Caj,
KeskiSäntti Harri,
Leivo Ilmo,
Mäkitie Antti,
PassadorSantos Fabricio,
Böckelman Camilla,
Salo Tuula,
Sorsa Timo,
Hagström Jaana
Publication year - 2012
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2011.01110.x
Subject(s) - medicine , matrix metalloproteinase , biomarker , cancer , pathology , basal cell , matrix metalloproteinase 9 , tongue , oncology , immunohistochemistry , biology , biochemistry
J Oral Pathol Med (2012) 41 : 394–399 Background: Oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. Mechanisms of this disease progression are not fully known. We aimed at finding new predictive markers for diagnosis and disease monitoring. Methods: Seventy‐three consecutive T1N0M0 and T2N0M0 OTSCC patients treated at Helsinki University Central Hospital, Helsinki, Finland, in 1992–2002 were included. Tissue array blocks were prepared from primary tumors and immunostained. Immunoexpression of matrix metalloproteinase (MMP)‐2, ‐8, ‐9, and ‐13 was compared with patient characteristics and outcome. Results: Nuclear expression of MMP‐13, but not cytoplasmic expression of MMP‐2, ‐8, and ‐9, was associated with invasion depth ( P = 0.017) and tumor size ( P = 0.008). Furthermore, high nuclear MMP‐13 expression was predictive of poor outcome ( P = 0.042). Conclusion: Our results suggest that especially MMP‐13 may be regarded as a prognostic biomarker in OTSCC.